Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

Cadherins play important roles in cell—cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (β-catenin/armadillo, plakoglobin, and α-catenin). Recent results show that β-catenin also binds to another cytoskeletal complex containing the adenomatous p...

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Published inCurrent opinion in cell biology Vol. 9; no. 5; pp. 683 - 690
Main Authors Barth, Angela IM, Näthke, Inke S, Nelson, W James
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1997
Subjects
Animals
Cadherins - physiology
Cytoskeletal Proteins - metabolism
Cytoskeleton - metabolism
Drosophila Proteins
Proto-Oncogene Proteins - physiology
Signal Transduction - physiology
Wnt1 Protein
TCF T cell factor
LEF-1 lymphoid enhancer-binding factor-1
GSK-3β glycogen synthase kinase-3β
EGF epidermal growth factor
HGF hepatocyte growth factor
PTP protein tyrosine phosphatase
APC adenomatous polyposis coli
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Summary:Cadherins play important roles in cell—cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (β-catenin/armadillo, plakoglobin, and α-catenin). Recent results show that β-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(97)80122-6