Clinical manifestations and treatment of Churg-Strauss syndrome

Churg-Strauss syndrome (CSS) is a systemic necrotizing vasculitis affecting small to medium-sized vessels, and characterized by asthma, blood hypereosinophilia, and eosinophil-rich granulomatous inflammation of the respiratory tract. In the past few years the pathogenesis of the disease and its clin...

Full description

Saved in:
Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 36; no. 3; p. 527
Main Authors Baldini, Chiara, Talarico, Rosaria, Della Rossa, Alessandra, Bombardieri, Stefano
Format Journal Article
LanguageEnglish
Published United States 01.08.2010
Subjects
Adrenal Cortex Hormones - administration & dosage
Antibodies, Antineutrophil Cytoplasmic - immunology
Antibodies, Monoclonal - therapeutic use
Asthma - complications
Asthma - immunology
Churg-Strauss Syndrome - complications
Churg-Strauss Syndrome - drug therapy
Churg-Strauss Syndrome - immunology
Drug Therapy, Combination
Eosinophilia - complications
Eosinophilia - drug therapy
Eosinophilia - immunology
Humans
Immunologic Factors - therapeutic use
Immunosuppressive Agents - administration & dosage
Remission Induction
Online AccessGet more information

Cover

More Information
Summary:Churg-Strauss syndrome (CSS) is a systemic necrotizing vasculitis affecting small to medium-sized vessels, and characterized by asthma, blood hypereosinophilia, and eosinophil-rich granulomatous inflammation of the respiratory tract. In the past few years the pathogenesis of the disease and its clinical manifestations have been clarified, fostering important advances in the treatment of CSS. Systemic corticosteroids are still considered the cornerstone of treatment. Many issues need to be addressed, such as how to maintain remission, prevent disease relapses, and treat refractory disease. This review provides a clinical overview of CSS and a summary of the current treatments and novel therapies.
ISSN:1558-3163
DOI:10.1016/j.rdc.2010.05.003