Control of the hematopoietic stem cell state

Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hem...

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Bibliographic Details
Published inCell research Vol. 24; no. 1; pp. 3 - 4
Main Authors Knapp, David JHF, Eaves, Connie J
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2014
Nature Publishing Group
Subjects
631/136/232/1473/1542
631/136/232/2051/1339
Animals
Biomedical and Life Sciences
Blood
Blood Platelets - cytology
Cell Biology
Cell Differentiation
Female
Hematopoietic Stem Cells - cytology
Life Sciences
Male
Research Highlight
Stem cells
再生过程
出版物
控制
细胞状态
自我更新
血小板
识别标志
造血干细胞
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Summary:Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin, but also subject to developmental and other, as yet undefined, cues.
Bibliography:Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin, but also subject to developmental and other, as yet undefined, cues.
31-1568/Q
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ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2013.139