Transcriptional Downregulation of ORF50/Rta by Methotrexate Inhibits the Switch of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 from Latency to Lytic Replication

• Published in: Journal of Virology Vol. 76; no. 10; pp. 5208 - 5219
• Main Authors: Curreli, Francesca, Cerimele, Francesca, Muralidhar, Sumitra, Rosenthal, Leonard J, Cesarman, Ethel, Friedman-Kien, Alvin E, Flore, Ornella
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.05.2002
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antiviral Agents - pharmacology; Cidofovir; Cytosine - analogs & derivatives; Cytosine - pharmacology; Down-Regulation; Drug Resistance; Foscarnet - pharmacology; Herpesvirus 8, Human - physiology; Humans; Immediate-Early Proteins - biosynthesis; Immediate-Early Proteins - genetics; Interleukin-6 - biosynthesis; Methotrexate - pharmacology; Neuropeptides - biosynthesis; Nucleic Acid Synthesis Inhibitors - pharmacology; Open Reading Frames; Organophosphonates; Organophosphorus Compounds - pharmacology; Trans-Activators - biosynthesis; Trans-Activators - genetics; Transcription, Genetic - drug effects; Tumor Cells, Cultured; Viral Proteins - biosynthesis; Virus Activation; Virus Latency - drug effects; Virus Replication
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.76.10.5208-5219.2002

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