The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal sc...
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| Published in | The journal of maternal-fetal & neonatal medicine Vol. 26; no. 2; pp. 143 - 145 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Taylor & Francis
01.01.2013
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| Subjects | |
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| Abstract | Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification. |
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| AbstractList | Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification. To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification. |
| Author | Wang, Eric Brar, Herb Norton, Mary E. Struble, Craig Musci, Thomas J. |
| Author_xml | – sequence: 1 givenname: Herb surname: Brar fullname: Brar, Herb organization: Riverside Perinatal Diagnostic Center – sequence: 2 givenname: Eric surname: Wang fullname: Wang, Eric organization: Ariosa Diagnostics – sequence: 3 givenname: Craig surname: Struble fullname: Struble, Craig organization: Ariosa Diagnostics – sequence: 4 givenname: Thomas J. surname: Musci fullname: Musci, Thomas J. email: tmusci@ariosadx.com organization: Ariosa Diagnostics – sequence: 5 givenname: Mary E. surname: Norton fullname: Norton, Mary E. organization: Stanford University/Lucile Packard Children's Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22913322$$D View this record in MEDLINE/PubMed |
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| References | 22839575 - J Matern Fetal Neonatal Med. 2012 Dec;25(12):2616-9 22742782 - Am J Obstet Gynecol. 2012 Aug;207(2):137.e1-8 22223233 - Prenat Diagn. 2012 Jan;32(1):3-9 22362253 - Obstet Gynecol. 2012 May;119(5):890-901 22070770 - J Matern Fetal Neonatal Med. 2012 Aug;25(8):1370-4 15569699 - Hum Reprod Update. 2005 Jan-Feb;11(1):59-67 14709639 - Clin Chem. 2004 Jan;50(1):88-92 22281937 - Genet Med. 2012 Mar;14(3):296-305 22464072 - Am J Obstet Gynecol. 2012 Apr;206(4):319.e1-9 22572044 - Fetal Diagn Ther. 2012;31(4):237-43 |
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| Snippet | Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A... To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. A comparative analysis... |
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| SubjectTerms | Adolescent Adult cell-free DNA DNA - blood Female Humans Maternal Age Middle Aged Non-invasive Nuchal Translucency Measurement Pregnancy prenatal diagnosis Risk Factors Trisomy - diagnosis trisomy risk Young Adult |
| Title | The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy |
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