The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy

Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal sc...

Full description

Saved in:
Bibliographic Details
Published inThe journal of maternal-fetal & neonatal medicine Vol. 26; no. 2; pp. 143 - 145
Main Authors Brar, Herb, Wang, Eric, Struble, Craig, Musci, Thomas J., Norton, Mary E.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2013
Subjects
Adolescent
Adult
cell-free DNA
DNA - blood
Female
Humans
Maternal Age
Middle Aged
Non-invasive
Nuchal Translucency Measurement
Pregnancy
prenatal diagnosis
Risk Factors
Trisomy - diagnosis
trisomy risk
Young Adult
Online AccessGet full text

Cover

More Information
Summary:Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2012.722731