Association between the ACE I/D gene polymorphism and physical performance in a homogeneous non-elite cohort

• Published in: Canadian journal of applied physiology Vol. 30; no. 1; p. 74
• Main Authors: Cam, F Sirri, Colakoglu, Muzaffer, Sekuri, Cevad, Colakoglu, Sule, Sahan, Cagatay, Berdeli, Afig
• Format: Journal Article
• Language: English
• Published: United States 01.02.2005
• Subjects: Alleles; Anaerobic Threshold - physiology; Cohort Studies; DNA Transposable Elements - genetics; Gene Deletion; Gene Frequency; Genotype; Humans; Male; Oxygen Consumption - physiology; Peptidyl-Dipeptidase A - genetics; Physical Endurance - genetics; Polymorphism, Genetic - genetics; Running - physiology; Weight Lifting - physiology
• ISSN: 1066-7814
• DOI: 10.1139/h05-106

I/D polymorphism of the ACE gene may be associated with better endurance performance and a stronger response to exercise training. The aim of this study was to investigate the association between ACE gene polymorphism and athletic performance in a homogeneous cohort. Eighty-eight male non-elite Caucasian Turkish athletes with similar training backgrounds for at least for 6 months were studied for ACE gene polymorphisms by PCR analysis. Performance on the 60-meter sprint and middle-distance running tests were evaluated. The distributions of the ACE I/D genotypes were 20.5%, 40.9%, and 38.6% for II, ID, and DD polymorphisms in the whole group (N = 88), respectively. The ACE DD genotype frequency was significantly higher in the superior group (56.7%) than in the poor (37.9%) and mediocre (20.7%) group in middle-distance running performance (chi2 = 11.778; p = 0.019). The ACE DD genotype may be related to better short-duration aerobic endurance performance. Larger homogeneous cohorts may help clarify the association between ACE I/D polymorphism and physical performance.