Clinical hip fracture is accompanied by compression induced failure in the superior cortex of the femoral neck

• Published in: Bone (New York, N.Y.) Vol. 108; pp. 121 - 131
• Main Authors: Tang, Tengteng, Cripton, Peter A., Guy, Pierre, McKay, Heather A., Wang, Rizhi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2018
• Subjects: Aged; Aged, 80 and over; Buckling; Compression; Female; Femoral neck cortex; Femur Neck - pathology; Fractures, Compression - pathology; Hip Fractures - pathology; Humans; Intra-capsular hip fracture; Laser scanning confocal microscopy; Male; Microcrack; Stress, Mechanical; Laser scanning confocal microscopy; Compression; Femoral neck cortex; Microcrack; Intra-capsular hip fracture; Buckling
• ISSN: 8756-3282; 1873-2763; 1873-2763
• DOI: 10.1016/j.bone.2017.12.020

Hip fractures pose a major health problem throughout the world due to their devastating impact. Current theories for why these injuries are so prevalent in the elderly point to an increased propensity to fall and decreases in bone mass with ageing. However, the fracture mechanisms, particularly the stress and strain conditions leading to bone failure at the hip remain unclear. Here, we directly examined the cortical bone from clinical intra-capsular hip fractures at a microscopic level, and found strong evidence of compression induced failure in the superior cortex. A total of 143 sections obtained from 24 femoral neck samples that were retrieved from 24 fracturing patients at surgery were examined using laser scanning confocal microscopy (LSCM) after fluorescein staining. The stained microcracks showed significantly higher density in the superior cortex than in the inferior cortex, indicating a greater magnitude of strain in the superior femoral neck during the failure-associated deformation and fracture process. The predominant stress state for each section was reconstructed based on the unique correlation between the microcrack pattern and the stress state. Specifically, we found clear evidence of longitudinal compression and buckling as the primary failure mechanisms in the superior cortex. These findings demonstrate the importance of microcrack analysis in studying clinical hip fractures, and point to the central role of the superior cortex failure as an important aspect of the failure initiation in clinical intra-capsular hip fractures. •The study provided direct evidence of microcracking in clinical hip fractures.•Superior femoral cortex tends to accumulate more microcracks than inferior cortex.•Longitudinal compression and buckling predominantly occur at superior cortex.•The results highlight the importance of superior cortex in a clinical hip fracture.