Bilateral serous retinal detachment: An initial presentation of mixed phenotype acute leukemia in an adult

A 60-year-old female presented with acute onset painless loss of vision in both eyes. Clinical examination and ocular investigations revealed bilateral serous retinal detachments (SRDs) over the macula. There was no obvious intraocular or extraocular cause to the presentation. A blood count showed l...

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Bibliographic Details
Published inOman journal of ophthalmology Vol. 15; no. 3; pp. 356 - 359
Main Authors Al Kalbani, Khulood, Al Hinai, Ahmed, Al Busaidi, Aisha
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.09.2022
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
Acute leukemia
Blindness
Cancer
Case Report
Chemotherapy
Genetic aspects
Genotype & phenotype
Leukemia
leukemic infiltration
mixed phenotype acute leukemia
Nervous system diseases
Ophthalmology
Retinal detachment
serous detachment
Valsartan
Vincristine
serous detachment
Leukemic infiltration
mixed phenotype acute leukemia
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Summary:A 60-year-old female presented with acute onset painless loss of vision in both eyes. Clinical examination and ocular investigations revealed bilateral serous retinal detachments (SRDs) over the macula. There was no obvious intraocular or extraocular cause to the presentation. A blood count showed leukocytosis with the presence of blast cells on the peripheral smear. Further workup confirmed the diagnosis of Philadelphia chromosome-positive mixed phenotype acute leukemia with central nervous system disease stage three. Anatomic improvement in the SRD followed intensive intravenous and intrathecal chemotherapy. Limited functional improvement was attributed to the development of pigment epitheliopathy manifesting as leopard spot chorioretinopathy. This permanent disturbance could be attributed to leukemic infiltration and ischemia to the choroid.
ISSN:0974-620X
0974-7842
DOI:10.4103/ojo.ojo_93_22