In silico screening for tumour-specific expressed sequences in human genome
A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been develo...
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Published in | FEBS letters Vol. 508; no. 1; pp. 143 - 148 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
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Elsevier B.V
09.11.2001
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Abstract | A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression. |
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AbstractList | A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression. |
Author | Ivanov, D.V. Lobashev, A.V. Baranova, A.V. Krukovskaya, L.L. Yankovsky, N.K. Kozlov, A.P. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11707285$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Cancer Computer-based differential display Databases, Genetic Expressed Sequence Tags Gene expression Gene Expression Profiling - methods Gene Library Genes, Neoplasm Genome, Human Humans Neoplasms - genetics |
Title | In silico screening for tumour-specific expressed sequences in human genome |
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