In silico screening for tumour-specific expressed sequences in human genome

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been develo...

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Published inFEBS letters Vol. 508; no. 1; pp. 143 - 148
Main Authors Baranova, A.V., Lobashev, A.V., Ivanov, D.V., Krukovskaya, L.L., Yankovsky, N.K., Kozlov, A.P.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 09.11.2001
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Abstract A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
AbstractList A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
Author Ivanov, D.V.
Lobashev, A.V.
Baranova, A.V.
Krukovskaya, L.L.
Yankovsky, N.K.
Kozlov, A.P.
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Keywords Gene expression
Computer-based differential display
Cancer
Language English
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Snippet A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of...
A computer‐based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of...
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SubjectTerms Cancer
Computer-based differential display
Databases, Genetic
Expressed Sequence Tags
Gene expression
Gene Expression Profiling - methods
Gene Library
Genes, Neoplasm
Genome, Human
Humans
Neoplasms - genetics
Title In silico screening for tumour-specific expressed sequences in human genome
URI https://dx.doi.org/10.1016/S0014-5793(01)03028-9
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