In silico screening for tumour-specific expressed sequences in human genome

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been develo...

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Bibliographic Details
Published inFEBS letters Vol. 508; no. 1; pp. 143 - 148
Main Authors Baranova, A.V., Lobashev, A.V., Ivanov, D.V., Krukovskaya, L.L., Yankovsky, N.K., Kozlov, A.P.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 09.11.2001
Subjects
Cancer
Computer-based differential display
Databases, Genetic
Expressed Sequence Tags
Gene expression
Gene Expression Profiling - methods
Gene Library
Genes, Neoplasm
Genome, Human
Humans
Neoplasms - genetics
Gene expression
Computer-based differential display
Cancer
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Summary:A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
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ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(01)03028-9