Effect of Continuous Glucose Monitoring on Glycemic Control, Acute Admissions, and Quality of Life: A Real-World Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 103; no. 3; pp. 1224 - 1232
• Main Authors: Charleer, Sara, Mathieu, Chantal, Nobels, Frank, De Block, Christophe, Radermecker, Regis P, Hermans, Michel P, Taes, Youri, Vercammen, Chris, TʼSjoen, Guy, Crenier, Laurent, Fieuws, Steffen, Keymeulen, Bart, Gillard, Pieter
• Format: Journal Article Web Resource
• Language: English
• Published: United States Copyright Oxford University Press 01.03.2018; Oxford University Press; The Endocrine Society
• Subjects: Absenteeism; Adult; Blood Glucose - analysis; Blood Glucose Self-Monitoring - methods; Blood Glucose Self-Monitoring - statistics & numerical data; Clinical trials; continuous; cost-effectiveness; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetic ketoacidosis; Endocrinologie, métabolisme & nutrition; Endocrinology, metabolism & nutrition; Fear; Female; Glucose; Glucose monitoring; Glycated Hemoglobin A - analysis; Hemoglobin; Hospitalization - statistics & numerical data; Human health sciences; Humans; Hypoglycemia; Hypoglycemia - etiology; Insulin; Ketoacidosis; Male; Middle Aged; Pregnancy complications; Prospective Studies; Quality of Life; real life; Sciences de la santé humaine; type1
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2017-02498

Randomized controlled trials evaluating real-time continuous glucose monitoring (RT-CGM) patients with type 1 diabetes (T1D) show improved glycemic control, but limited data are available on real-world use. To assess impact of RT-CGM in real-world settings on glycemic control, hospital admissions, work absenteeism, and quality of life (QOL). Prospective, observational, multicenter, cohort study. A total of 515 adults with T1D on continuous subcutaneous insulin infusion (CSII) therapy starting in the Belgian RT-CGM reimbursement program. Initiation of RT-CGM reimbursement. Hemoglobin A1c (HbA1c) evolution from baseline to 12 months. Between September 1, 2014, and December 31, 2016, 515 adults entered the reimbursement system. Over this period, 417 (81%) patients used RT-CGM for at least 12 months. Baseline HbA1c was 7.7 ± 0.9% (61 ± 9.8 mmol/mol) and decreased to 7.4 ± 0.8% (57 ± 8.7 mmol/mol) at 12 months (P < 0.0001). Subjects who started RT-CGM because of insufficient glycemic control showed stronger decrease in HbA1c at 4, 8, and 12 months compared with patients who started because of hypoglycemia or pregnancy. In the year preceding reimbursement, 16% of patients were hospitalized for severe hypoglycemia or ketoacidosis in contrast to 4% (P < 0.0005) the following year, with decrease in admission days from 54 to 18 per 100 patient years (P < 0.0005). In the same period, work absenteeism decreased and QOL improved significantly, with strong decline in fear of hypoglycemia. Sensor-augmented pump therapy in patients with T1D followed in specialized centers improves HbA1c, fear of hypoglycemia, and QOL, whereas work absenteeism and admissions for acute diabetes complications decreased.