Combining Treatment Selection and Definitive Testing

• Published in: Biometrical journal Vol. 48; no. 4; pp. 690 - 692
• Main Authors: Proschan, Michael A., Hunsberger, Sally A.
• Format: Journal Article
• Language: English
• Published: Berlin WILEY-VCH Verlag 01.08.2006; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Adaptive design; Adaptive hierarchical test; Adaptive methods; Applications; Biology, psychology, social sciences; Clinical Trials as Topic - statistics & numerical data; Comparisons with control; Conditional error function; Critical value; Data Interpretation, Statistical; Dropping treatments; Dunnett's procedure; Exact sciences and technology; Experimental design; Interim look; Many-one comparison; Mathematics; Medical sciences; Models, Statistical; Multiple comparisons; Optimal design; Probability and statistics; Reallocation of sample size; Research Design - statistics & numerical data; Safety data; Safety monitoring rules; Sciences and techniques of general use; Statistics; Treatment selection; Biometrics; Adaptive design; Interim look; Conditional distribution; Dropping treatments; Error estimation; Many-one comparison; Dunnett's procedure; Safety data; Adaptive method; Comparisons with control; Optimal design; Conditional error function; Statistical test; Treatment selection; Multiple comparisons; Comparison test; Safety; Critical value; Life science; Error function; Multiple comparison; Adaptive hierarchical test; Reallocation of sample size; Safety monitoring rules; Statistical method; Adaptive methods; Experimental design; Hierarchical test; Optimal design(statistics)
• ISSN: 0323-3847; 1521-4036
• DOI: 10.1002/bimj.200610247

This is a discussion of the following two papers appearing in this special issue on adaptive designs: ‘An adaptive hierarchical test procedure for selecting safe and efficient treatments’ by Franz König, Peter Bauer and Werner Brannath, and ‘An adaptive two‐stage design with treatment selection using the conditional error function approach’ by Jixian Wang. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)