Cytokeratin expression in chondroblastomas

The present study is based on the histopathological and immunohistochemical examination of seven chondroblastomas, including one lung metastasis occurring 9 years after treatment. Chondroblastomas were shown to co-express vimentin, S-100 protein, neuron-specific enolase, and the epithelial markers r...

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Bibliographic Details
Published inHistopathology Vol. 16; no. 3; p. 257
Main Authors Semmelink, H J, Pruszczynski, M, Wiersma-van Tilburg, A, Smedts, F, Ramaekers, F C
Format Journal Article
LanguageEnglish
Published England 01.03.1990
Subjects
Adolescent
Adult
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Chondroblastoma - metabolism
Chondroblastoma - pathology
Female
Humans
Immunohistochemistry
Keratins - metabolism
Male
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Summary:The present study is based on the histopathological and immunohistochemical examination of seven chondroblastomas, including one lung metastasis occurring 9 years after treatment. Chondroblastomas were shown to co-express vimentin, S-100 protein, neuron-specific enolase, and the epithelial markers recognized by CAM 5.2, EMA and a polyclonal cytokeratin antibody. The cytokeratins present in the tumour cells of the lung metastasis were characterized as cytokeratins 8, 18, 19 and, to a lesser extent, cytokeratin 7. The results suggest aberrant cytokeratin expression in chrondroblastomas.
ISSN:0309-0167
DOI:10.1111/j.1365-2559.1990.tb01112.x