Liver transplantation for acute liver failure: outcome analysis

Acute liver failure (ALF) remains a major cause of morbidity and mortality. Before the availability of liver transplantation only 20% of patients with ALF survived. The clinical dilemma relates to the prognostication of these patients, as early liver transplantation has been associated with better o...

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Bibliographic Details
Published inJournal of viral hepatitis Vol. 4; no. s1; pp. 107 - 110
Main Authors Shakil, A. O., Dvorchik, I., Fung, J. J., Rakela, J.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.1997
Subjects
Acute Disease
encephalopathy
fulminant hepatic failure
hepatic necrosis
Humans
Liver Failure - therapy
Liver Transplantation
liver volume
prognostic factors
Treatment Outcome
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Summary:Acute liver failure (ALF) remains a major cause of morbidity and mortality. Before the availability of liver transplantation only 20% of patients with ALF survived. The clinical dilemma relates to the prognostication of these patients, as early liver transplantation has been associated with better outcomes. The eligibility for liver transplantation must therefore be quickly established. The patient's age, aetiology of disease, interval between the onset of jaundice and encephalopathy, blood pH, prothrombin time, serum bilirubin and serum creatinine levels has been identified as useful prognostic markers. The degree of hepatocyte necrosis on liver biopsy and estimated hepatic volume by computed tomography may also be valuable predictors of survival; however, further studies are needed.
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ISSN:1352-0504
1365-2893
DOI:10.1111/j.1365-2893.1997.tb00170.x