Malignant lymphoma of mucosa-associated lymphoid tissue

Lymphomas of the gastrointestinal tract, salivary glands, lung and thyroid are grouped together as tumours arising in mucosa-associated lymphoid tissue. The great majority of them are of B-cell origin but distinctive T-cell lymphomas are also recognized in the gastrointestinal tract. These lymphomas...

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Bibliographic Details
Published inHistopathology Vol. 11; no. 5; p. 445
Main Authors Isaacson, P G, Spencer, J
Format Journal Article
LanguageEnglish
Published England 01.05.1987
Subjects
B-Lymphocytes - pathology
Humans
Immunochemistry
Lymphoid Tissue - pathology
Lymphoma - immunology
Lymphoma - pathology
Mucous Membrane - pathology
Stomach Neoplasms - immunology
Stomach Neoplasms - pathology
T-Lymphocytes - pathology
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Summary:Lymphomas of the gastrointestinal tract, salivary glands, lung and thyroid are grouped together as tumours arising in mucosa-associated lymphoid tissue. The great majority of them are of B-cell origin but distinctive T-cell lymphomas are also recognized in the gastrointestinal tract. These lymphomas tend to remain localized for prolonged periods but, whereas the B-cell group respond favourably to local therapy, the T-cell group are associated with severe morbidity and their overall prognosis is extremely poor. Accepted histological classifications of non-Hodgkin's lymphomas are difficult to apply to these tumours. In this paper their morphological features are reviewed; recent findings based on immunohistochemistry and DNA analysis are presented; and the biological behaviour of these tumours is discussed insofar as they offer insight into mucosal immunological mechanisms.
ISSN:0309-0167
DOI:10.1111/j.1365-2559.1987.tb02654.x