q-Space imaging of the brain

q-Space imaging (Callaghan, J. Magn. Reson. 88, 493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherent-displacement probability density distribution. Two groups of mice were studied, a normal group and one in which sur...

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Bibliographic Details
Published inMagnetic resonance in medicine Vol. 32; no. 6; p. 707
Main Authors King, M D, Houseman, J, Roussel, S A, van Bruggen, N, Williams, S R, Gadian, D G
Format Journal Article
LanguageEnglish
Published United States 01.12.1994
Subjects
Animals
Body Water - metabolism
Brain - anatomy & histology
Brain - pathology
Brain Chemistry
Brain Ischemia - diagnosis
Brain Ischemia - metabolism
Diffusion
Feasibility Studies
Female
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred BALB C
Models, Structural
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Summary:q-Space imaging (Callaghan, J. Magn. Reson. 88, 493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherent-displacement probability density distribution. Two groups of mice were studied, a normal group and one in which surgery had been performed to reduce the supply of blood to the forebrain. In the normal group the incoherent displacement of water was reduced postmortem. Four of the surgically treated mice yielded displacement profiles that resembled those obtained postmortem; the remaining two were near normal. This study demonstrates the feasibility of in vivo q-space imaging. The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusion-weighted imaging.
ISSN:0740-3194
DOI:10.1002/mrm.1910320605