ROS‐driven cellular methane formation: Potential implications for health sciences

Recently it has been proposed that methane might be produced by all living organisms via a mechanism driven by reactive oxygen species that arise through the metabolic activity of cells. Here, we summarise details of this novel reaction pathway and discuss its potential significance for clinical and...

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Bibliographic Details
Published inClinical and translational medicine Vol. 12; no. 7; pp. e905 - n/a
Main Authors Keppler, Frank, Ernst, Leonard, Polag, Daniela, Zhang, Jingyao, Boros, Mihaly
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.07.2022
John Wiley and Sons Inc
Wiley
Subjects
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants - metabolism
Antioxidants - pharmacology
Biological activity
Clinical medicine
Gases
Health sciences
Infectious diseases
Iron
Mammals - metabolism
Metabolism
Methane - pharmacology
Oxidative Stress
Reactive Oxygen Species - metabolism
Reactive Oxygen Species - pharmacology
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Summary:Recently it has been proposed that methane might be produced by all living organisms via a mechanism driven by reactive oxygen species that arise through the metabolic activity of cells. Here, we summarise details of this novel reaction pathway and discuss its potential significance for clinical and health sciences. In particular, we highlight the role of oxidative stress in cellular methane formation. As several recent studies also demonstrated the anti‐inflammatory potential for exogenous methane‐based approaches in mammalians, this article addresses the intriguing question if ROS‐driven methane formation has a general physiological role and associated diagnostic potential.
Bibliography:SourceType-Scholarly Journals-1
content type line 23
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.905