Relaxivity enhancement of low molecular weight nitroxide stable free radicals: importance of structure and medium

The longitudinal relaxivities of seven water-soluble nitroxide derivatives of low-molecular weight have been measured at 5 degrees C and 37 degrees C in water and in serum between 0.01 and 200 MHz. The nuclear magnetic relaxation dispersion (NMRD) profiles show a clear relationship between the relax...

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Bibliographic Details
Published inMagnetic resonance in medicine Vol. 32; no. 1; p. 11
Main Authors Vallet, P, Van Haverbeke, Y, Bonnet, P A, Subra, G, Chapat, J P, Muller, R N
Format Journal Article
LanguageEnglish
Published United States 01.07.1994
Subjects
Cyclic N-Oxides
Free Radicals
Humans
Magnetic Resonance Spectroscopy
Molecular Weight
Nitrogen Oxides - blood
Nitrogen Oxides - chemistry
Spin Labels
Structure-Activity Relationship
Water
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Summary:The longitudinal relaxivities of seven water-soluble nitroxide derivatives of low-molecular weight have been measured at 5 degrees C and 37 degrees C in water and in serum between 0.01 and 200 MHz. The nuclear magnetic relaxation dispersion (NMRD) profiles show a clear relationship between the relaxivity observed in serum and the relative balance of the hydrophobic/hydrophilic character of the paramagnetic molecules. From the data analysis, contributions arising from a population of nitroxides characterized by reduced mobility can be extracted. The values of the correlation times are consistent with a system involving nitroxides adsorbed at the surface of albumin and magnetically interacting with the protons of hydrogen bonded water molecules.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.1910320103