Favorable outcome to glucocorticoid therapy for engraftment syndrome in pediatric autologous hematopoietic cell transplant

• Published in: Pediatric transplantation Vol. 20; no. 2; pp. 297 - 302
• Main Authors: Abongwa, Chenue, Abu-Arja, Rolla, Rumelhart, Stephen, Lazarus, Hillard M., Abusin, Ghada
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.03.2016
• Subjects: Adolescent; Antineoplastic Agents - therapeutic use; Child; Child, Preschool; engraftment syndrome; Female; glucocorticoid; Glucocorticoids - therapeutic use; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Length of Stay; Male; Neoplasms - therapy; pediatric autologous hematopoietic cell transplant; pediatrics; peri-engraftment; Retrospective Studies; Risk Factors; Steroids - therapeutic use; Surveys and Questionnaires; Transplantation Conditioning - methods; Treatment Outcome; Young Adult; glucocorticoid; pediatric autologous hematopoietic cell transplant; peri-engraftment; engraftment syndrome; pediatrics
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.12652

ES remains an important cause of morbidity and mortality in children undergoing auto‐HCT. Glucocorticoid use in ES is an area of debate. We retrospectively analyzed single‐institution experience from September 2000 through December 2012 to evaluate the use of glucocorticoids in auto‐HCT patients. ES was defined by the occurrence of new onset of non‐infectious fever plus diarrhea, rash, or pulmonary infiltrates 24‐h before or within five days after neutrophil engraftment. Sixty‐five pediatric patients (<21 yr) with different solid tumors underwent auto‐HCTs in the study period. Fifteen patients (23%) fulfilled criteria for ES, of which 13 received methylprednisolone (2 mg/kg IV for 3–5 days). Clinical improvement occurred in all patients within 48 h without significant complications. In the non‐ES group, 11 patients received glucocorticoid without significant complications as well. MEL‐based regimens were found to be significant factor for ES (p < 0.05). Fever, edema, non‐infectious diarrhea, and serum albumin concentration were statistically different between the two groups. Median hospital length of stay was higher in the ES group. Conclusion: ES is a common complication in children after auto‐HCT and short‐course glucocorticoid therapy is an effective and well‐tolerated treatment, even in those who did not completely fulfill diagnostic criteria.