Cytotoxicity of three resin-based root canal sealers: an in vitro evaluation

The cytotoxicity of three resin-based root canal sealers (AH26, AH-Plus, Topseal) was evaluated in vitro. The experiments included two cell lines, L929 mouse skin fibroblasts and RPC-C2A rat pulp cells. The cytotoxicity was assessed by sulforodamine B (SRB) colorimetric assay and hemocytometer viabl...

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Published inEndodontics & dental traumatology Vol. 14; no. 4; p. 182
Main Authors Koulaouzidou, E A, Papazisis, K T, Beltes, P, Geromichalos, G D, Kortsaris, A H
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1998
Subjects
Animals
Bismuth - toxicity
Cells, Cultured
Dental Pulp - cytology
Dental Pulp - drug effects
Drug Combinations
Epoxy Resins - toxicity
Fibroblasts - drug effects
L Cells (Cell Line) - drug effects
Methenamine - toxicity
Mice
Rats
Root Canal Filling Materials - toxicity
Silver - toxicity
Titanium - toxicity
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Summary:The cytotoxicity of three resin-based root canal sealers (AH26, AH-Plus, Topseal) was evaluated in vitro. The experiments included two cell lines, L929 mouse skin fibroblasts and RPC-C2A rat pulp cells. The cytotoxicity was assessed by sulforodamine B (SRB) colorimetric assay and hemocytometer viable cell counting after 24- and 48-h exposure. AH26 had a severe cytotoxic effect whilst Topseal and AH-Plus showed a markedly lower toxic influence on the cells during the experimental period.
ISSN:0109-2502
DOI:10.1111/j.1600-9657.1998.tb00834.x