Molecular genetic study of the gutter shaped root (GSR) on mouse chromosome 17

In this study, a genetic factor affecting the appearance of the gutter-shaped root (GSR) in mice was examined using two inbred strains of mice, C57L/J and C57BL/6, J, and the genetic crosses of these strains. 120 Mit markers, which exist on mouse chromosome 17, have been investigated to select polym...

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Bibliographic Details
Published inJournal of Oral Science Vol. 42; no. 1; pp. 21 - 26
Main Author Matsune, Kensuke
Format Journal Article
LanguageEnglish
Published Japan Nihon University School of Dentistry 2000
Subjects
Animals
Chromosome Mapping
Dentistry
Genetic Linkage
Gutter-shaped root
inbred mouse
linkage analysis
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Tooth Abnormalities - genetics
tooth anomaly
Tooth Root - abnormalities
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Summary:In this study, a genetic factor affecting the appearance of the gutter-shaped root (GSR) in mice was examined using two inbred strains of mice, C57L/J and C57BL/6, J, and the genetic crosses of these strains. 120 Mit markers, which exist on mouse chromosome 17, have been investigated to select polymorphic markers between the two strains. Nine Mit markers with polymorphism between the two strains were obtained using polymerase chain reaction (PCR). To detect the individual genotype of 66 backcross mice, simple sequence lengthÁ polymorphism (SSLP) analysis was performed. From the results of individual genotyping using 9 informative markers, the highest linkage was determined at D17Mit260. Based on these findings, it was suggested that the gene causing the mouse GSR might be located on mouse chromosome 17 and nearby D17Mit260. (J. Oral Sci. 42, 21-26, 2000)
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ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.42.21