Usefulness of Measuring Serum Procalcitonin Levels in Patients with Inflammatory Bowel Disease

• Published in: Gut and liver Vol. 10; no. 4; pp. 574 - 580
• Main Authors: Chung, Sook Hee, Lee, Hye Won, Kim, Seung Won, Park, Soo Jung, Hong, Sung Pil, Kim, Tae Il, Kim, Won Ho, Cheon, Jae Hee
• Format: Journal Article
• Language: English
• Published: Korea (South) Editorial Office of Gut and Liver 01.07.2016; Gastroenterology Council for Gut and Liver; 거트앤리버 소화기연관학회협의회
• Subjects: Adult; Behcet Syndrome - blood; Behcet Syndrome - microbiology; Biomarkers - blood; C-Reactive Protein - analysis; Calcitonin - blood; disease activity; Female; Humans; infection; inflammatory bowel disease; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - microbiology; intestinal beh?et’s disease; Male; Middle Aged; Original; Predictive Value of Tests; procalcitonin; Retrospective Studies; Sepsis - blood; Sepsis - diagnosis; Sepsis - microbiology; Severity of Illness Index; Young Adult; 내과학; Infection; Inflammatory bowel disease; Intestinal Behçet’s disease; Disease activity; Procalcitonin
• ISSN: 1976-2283; 2005-1212; 2005-1212
• DOI: 10.5009/gnl15209

The relationships between serum procalcitonin, inflammatory bowel disease (IBD) and intestinal Behçet's disease (BD) have not been completely determined. We aimed to evaluate the usefulness of measuring serum procalcitonin levels to assess disease activity and infection stage in patients with IBD and intestinal BD. We retrospectively analyzed clinical data from 129 patients with IBD and intestinal BD for whom serum procalcitonin and C-reactive protein (CRP) levels were measured between January 2006 and February 2013. The median serum procalcitonin levels in the IBD and intestinal BD with septic shock or sepsis (n=8), with localized infection (n=76), and without infection (n=45) were 3.46 ng/mL (range, 0.17 to 63.66 ng/mL), 0.22 ng/mL (range, 0.05 to 140.18 ng/mL), and 0.07 ng/mL (range, 0.00 to 31.50 ng/mL), respectively (p=0.001). The serum CRP levels in the IBD and intestinal BD patients did not differ according to the infection stage. Variations in serum procalcitonin levels were not observed in the IBD and intestinal BD patients with different disease activities. Serum procalcitonin levels may not be affected by IBD and intestinal BD activity itself, although they may be affected by concomitant infection. Serum procalcitonin measurements could be more useful than CRP in determining the infection stage that reflects the severity of infection in IBD and intestinal BD patients.