Associations of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life
Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal...
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Published in | Nutrients Vol. 14; no. 1; p. 15 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
21.12.2021
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal measurements of 25(OH)D and hs-CRP, respectively, from pregnancy to childhood and throughout childhood in two Danish mother-child cohorts-the COPSAC
and COPSAC
. In COPSAC
, there was an association between 25(OH)D concentrations at week 24 in pregnancy and at age 6 months in childhood (
633): estimate (95% CI); 0.114 (0.041;0.187),
0.002, and between 25(OH)D at age 6 months and 6 years (
475): 0.155 (0.083;0.228),
0.001. This was also demonstrated in the COPSAC
cohort between 25(OH)D concentrations in cord blood and at age 4 years (
188): 0.294 (0.127;0.461),
0.001 and at age 6 months and 4 years (
264): 0.260 (0.133;0.388),
0.001. In COPSAC
, we also found an association between hs-CRP at age 6 months and 12 years in childhood (
232): 0.183 (0.076;0.289),
0.001. Finally, we found a negative association between the cross-sectional measurements of 25(OH)D and hs-CRP at age 6 months (
613) in COPSAC
: -0.004 (-0.008;-0.0004),
0.030, but this was not replicated in COPSAC
. In this study, we found evidence of associations across timepoints of 25(OH)D concentrations from mid-pregnancy to infancy and through childhood and associations between hs-CRP levels during childhood, although with weak correlations. We also found a negative cross-sectional association between 25(OH)D and hs-CRP concentrations in COPSAC
proposing a role of vitamin D in systemic low-grade inflammation, though this association was not present in COPSAC
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2072-6643 2072-6643 |
DOI: | 10.3390/nu14010015 |