Computational fluid dynamics modeling aiding surgical planning in a toddler with Parkes Weber syndrome

• Published in: Journal of pediatric surgery case reports Vol. 66; p. 101780
• Main Authors: Peñalver, Josiah M., Bennett, James T., Nelson, Zoe, Bly, Randall A., Perkins, Jonathan A., Bull, Catherine V., Aliseda, Alberto, Chassagne, Fanette, Shivaram, Giridhar M., Lindberg, Antoinette W., Waldhausen, John H.T., Nuri, Muhammad A.K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2021; Elsevier
• Subjects: Arterial banding; Computational fluid dynamics modeling; Congestive heart failure; MAP2K1 mutation; Parkes Weber syndrome; CFD; Computational fluid dynamics modeling; Congestive heart failure; Parkes Weber syndrome; MAP2K1 mutation; Arterial banding
• ISSN: 2213-5766; 2213-5766
• DOI: 10.1016/j.epsc.2021.101780

Parkes Weber syndrome is a fast-flow and slow-flow vascular anomaly with limb overgrowth that can lead to congestive heart failure and limb ischemia. Current management strategies have focused on symptom management with focal embolization. A pediatric case with early onset heart failure is reported. We discuss the use of computational fluid dynamics (CFD) modeling to guide a surgical management strategy in a toddler with an MAP2K1 mutation. ●Use of flow dynamics modeling to aid in surgical planning in Parkes Weber syndrome●Unique surgical strategy to address pediatric over-circulation due to a large vascular anomaly●Identification of MAP2K1 mutation guiding potential therapy using MEK1 inhibitors