Complement Depletion Improves Neurological Function in Cerebral Ischemia

• Published in: Brain research bulletin Vol. 45; no. 4; pp. 413 - 419
• Main Authors: Vasthare, U.S, Barone, F.C, Sarau, H.M, Rosenwasser, R.H, DiMartino, M, Young, William F, Tuma, R.F
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1998; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Brain Ischemia - physiopathology; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Cobra venom factor; Complement Inactivator Proteins - pharmacology; Complement system; Complement System Proteins - physiology; Elapid Venoms - pharmacology; Evoked potentials; Evoked Potentials, Somatosensory - physiology; Hemolysis - physiology; Medical sciences; Myeloperoxidase; Neurology; Neutrophils; Peroxidase - metabolism; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4 - metabolism; Transient forebrain ischemia; Vascular diseases and vascular malformations of the nervous system; Vascular Resistance - physiology; Myeloperoxidase; Transient forebrain ischemia; Complement system; Cobra venom factor; Evoked potentials; Neutrophils; Nervous system diseases; Rat; Rodentia; Electrophysiology; Cardiovascular disease; Complement; Transitory; Cerebral disorder; Vascular disease; Vertebrata; Experimental disease; Mammalia; Depletion; Ischemia; Evoked potential; Animal; Central nervous system disease; Neutrophil; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/S0361-9230(97)00408-5

The contribution of the complement system to the exacerbation of cerebral ischemia/reperfusion injury was studied by comparing a group of rats with normal complement levels to another group that was complement depleted by cobra venom factor (CVF). The magnitude of reactive hyperemia was significantly greater in the complement depleted animals. There was also better preservation of somatosensory evoked potentials (SSEPs) in the complement depleted animals. These differences were not associated with changes in leukocyte infiltration as evidenced by myeloperoxidase and Leukotriene B 4 activity. These data demonstrate that depleting the complement system can improve flow and outcome following cerebral ischemia with reperfusion.