Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy

• Published in: Marine drugs Vol. 17; no. 2; p. 77
• Main Authors: Yuan, Mei-Xiang, Qiu, Yi, Ran, Yan-Qin, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Lan, Wen-Jian, Li, Hou-Jin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.01.2019; MDPI
• Subjects: Alkaloids; Amino acid composition; Amino acids; Biological activity; Cancer; Cell culture; Cell lines; Culture media; cytotoxic activity; Cytotoxicity; Fungi; Hydrocarbons; indole alkaloid; Indoles; Metabolites; NMR; Nuclear magnetic resonance; Pseudallescheria boydii; pseudboindole; Tumor cell lines; indole alkaloid; pseudboindole; cytotoxic activity; Pseudallescheria boydii

The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated...