Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy

The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated...

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Published inMarine drugs Vol. 17; no. 2; p. 77
Main Authors Yuan, Mei-Xiang, Qiu, Yi, Ran, Yan-Qin, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Lan, Wen-Jian, Li, Hou-Jin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.01.2019
MDPI
Subjects
Alkaloids
Amino acid composition
Amino acids
Biological activity
Cancer
Cell culture
Cell lines
Culture media
cytotoxic activity
Cytotoxicity
Fungi
Hydrocarbons
indole alkaloid
Indoles
Metabolites
NMR
Nuclear magnetic resonance
Pseudallescheria boydii
pseudboindole
Tumor cell lines
indole alkaloid
pseudboindole
cytotoxic activity
Pseudallescheria boydii
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Summary:The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2), together with 11 known indole alkaloids were isolated from the culture broth. Their structures were elucidated by comprehensive analysis of the NMR, MS, IR, and UV spectra. The 3,3′-cyclohexylidenebis(1H-indole) (3) showed cytotoxic activity against various cancer cell lines.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md17020077