Vibrational Spectroscopy Fingerprinting in Medicine: from Molecular to Clinical Practice

In the last two decades, Fourier Transform Infrared (FTIR) and Raman spectroscopies turn out to be valuable tools, capable of providing fingerprint-type information on the composition and structural conformation of specific molecular species. Vibrational spectroscopy’s multiple features, namely high...

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Published inMaterials Vol. 12; no. 18; p. 2884
Main Authors Balan, Vera, Mihai, Cosmin-Teodor, Cojocaru, Florina-Daniela, Uritu, Cristina-Mariana, Dodi, Gianina, Botezat, Doru, Gardikiotis, Ioannis
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.09.2019
MDPI
Subjects
Biomedical materials
Carbohydrates
Cell cycle
Data processing
Deoxyribonucleic acid
DNA
Fingerprinting
Fourier transforms
Infrared spectroscopy
Lipids
Nondestructive testing
Pathogenesis
Peptides
Proteins
Radiation
Reagents
Reproducibility
Review
Software
Spectrum analysis
Vibration
fingerprint
in vivo
clinic
fourier transform infrared spectroscopy
Raman spectroscopy
ex vivo
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Summary:In the last two decades, Fourier Transform Infrared (FTIR) and Raman spectroscopies turn out to be valuable tools, capable of providing fingerprint-type information on the composition and structural conformation of specific molecular species. Vibrational spectroscopy’s multiple features, namely highly sensitive to changes at the molecular level, noninvasive, nondestructive, reagent-free, and waste-free analysis, illustrate the potential in biomedical field. In light of this, the current work features recent data and major trends in spectroscopic analyses going from in vivo measurements up to ex vivo extracted and processed materials. The ability to offer insights into the structural variations underpinning pathogenesis of diseases could provide a platform for disease diagnosis and therapy effectiveness evaluation as a future standard clinical tool.
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ISSN:1996-1944
1996-1944
DOI:10.3390/ma12182884