Bisphenol A and its analogs: Do their metabolites have endocrine activity?

• Published in: Environmental toxicology and pharmacology Vol. 47; pp. 182 - 199
• Main Authors: GramecSkledar, Darja, Peterlin Mašič, Lucija
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2016; Elsevier Science Ltd
• Subjects: Analogs; Animals; Benzhydryl Compounds - metabolism; Benzhydryl Compounds - toxicity; Bisphenol A; Bisphenols; BPA analogs; Detoxification; Emergency; Endocrine Disruptors - chemistry; Endocrine Disruptors - metabolism; Endocrine Disruptors - toxicity; Endocrine system; Endocrine toxicity; Estrogens; Glucuronidation; Hormone disruptors; Humans; Literature reviews; Mass production; Metabolic pathways; Metabolites; Oxidative metabolism; Phenols; Phenols - metabolism; Phenols - toxicity; Plastics; Polybrominated Biphenyls - metabolism; Polybrominated Biphenyls - toxicity; Receptors; Sulfones - metabolism; Sulfones - toxicity; Toxicity; NADPH; UGT; BPS; tetrabromobisphenol A (2,2′,6,6′-tetrabromo-4,4′-isopropylidenediphenol); SULT; hormone disruptors; bisphenol B, (2,2-bis(4-hydroxyphenyl)butane); CYP450; bisphenol AF (1,1,1,3,3,3-hexafluoro-2,2-bis (4-hydroxyphenyl)propane); MBP; glucuronidation; oxidative metabolism; estrogen receptor; nicotinamide adenine dinucleotide phosphate; DMBPA; cytochrome P450; sulfotransferase; BPAF; 4-methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene; ER; BPA; uridine 5′-diphospho-glucuronosyltransferase; endocrine toxicity; bisphenol A (4,4′-(propane-2,2-diyl)diphenol); BPB; BPF; ERE; bisphenol A; estrogen-responsive element; TBBPA; bisphenol F (bis(4-hydroxyphenyl)methane); bisphenol S (bis[4-hydroxyphenyl]sulfone); BPA analogs; dimethylbisphenol A; Glucuronidation; Oxidative metabolism; Bisphenol A; Endocrine toxicity; Hormone disruptors
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2016.09.014

Highlights • Bisphenols are mainly metabolized by glucuronidation to their glucuronides • Oxidative metabolism is only a minor metabolic pathway • Oxidative metabolites with highly enhanced endocrine activity are detected. • Bisphenol glucuronides have no activities on estrogen receptors.