Bisphenol A and its analogs: Do their metabolites have endocrine activity?

Highlights • Bisphenols are mainly metabolized by glucuronidation to their glucuronides • Oxidative metabolism is only a minor metabolic pathway • Oxidative metabolites with highly enhanced endocrine activity are detected. • Bisphenol glucuronides have no activities on estrogen receptors.

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Bibliographic Details
Published inEnvironmental toxicology and pharmacology Vol. 47; pp. 182 - 199
Main Authors GramecSkledar, Darja, Peterlin Mašič, Lucija
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2016
Elsevier Science Ltd
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Summary:Highlights • Bisphenols are mainly metabolized by glucuronidation to their glucuronides • Oxidative metabolism is only a minor metabolic pathway • Oxidative metabolites with highly enhanced endocrine activity are detected. • Bisphenol glucuronides have no activities on estrogen receptors.
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ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.09.014