Hypolipidemic Effect of Arthrospira ( Spirulina ) maxima Supplementation and a Systematic Physical Exercise Program in Overweight and Obese Men: A Double-Blind, Randomized, and Crossover Controlled Trial

• Published in: Marine drugs Vol. 17; no. 5; p. 270
• Main Authors: Hernández-Lepe, Marco Antonio, Wall-Medrano, Abraham, López-Díaz, José Alberto, Juárez-Oropeza, Marco Antonio, Hernández-Torres, Rosa Patricia, Ramos-Jiménez, Arnulfo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.05.2019; MDPI
• Subjects: Arthrospira; Arthrospira maxima; Body mass index; Body weight; Cholesterol; Crossovers; Density; Dietary supplements; double-blind; Double-blind studies; Dyslipidemia; Exercise; Functional foods & nutraceuticals; Lipids; Lipoproteins; Low fat diet; Men; Metabolic disorders; Nutrient deficiency; Obesity; Physical activity; Physical exercise; Physical training; Placebos; randomized controlled trial; Spectrophotometry; Spirulina; Spirulina maxima; Subgroups; Synergistic effect; Training; Triglycerides; Arthrospira maxima; dyslipidemia; physical exercise; double-blind; obesity; randomized controlled trial
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md17050270

Low-fat diets, lipid-modifying nutraceuticals and a higher level of physical activity are often recommended to reduce dyslipidemia. A double-blind, randomized, crossover, controlled trial was designed to evaluate the independent and synergistic effects of ( ) supplementation (4.5 g·day ) with or without performing a physical exercise program ( : aerobic exercise (3 days·week ) + high-intensity interval training (2 days·week )) on blood lipids and BMI of 52 sedentary men with excess body weight. During six weeks, all participants were assigned to four intervention treatments ( with PEP (SE), placebo with PEP (Ex), without PEP (Sm), placebo without PEP (C; control)) and plasma lipids were evaluated spectrophotometrically pre- vs. post intervention in stratified subgroups (overweight, obese and dyslipidemic subjects). Pre/post comparisons showed significant reductions in all plasma lipids in the SE group, particularly in those with dyslipidemia ( ≤ 0.043). Comparing the final vs. the initial values, BMI, total cholesterol, triglycerides and low-density lipoprotein cholesterol were decreased. High-density lipoprotein cholesterol increased in all treatment groups compared to C. Changes were observed mostly in SE interventions, particularly in dyslipidemic subjects ( < 0.05). supplementation enhances the hypolipidemic effect of a systematic PEP in men with excess body weight and dyslipidemia.