Dietary Intake and Counseling, Weight Maintenance, and the Course of HIV Infection

• Published in: Journal of the American Dietetic Association Vol. 95; no. 4; pp. 428 - 435
• Main Authors: CHLEBOWSKI, ROWAN T, GROSVENOR, MARY, LILLINGTON, LINDA, SAYRE, JAMES, BEALL, GILDON
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1995; Elsevier; Elsevier Science Publishers; Elsevier Limited
• Subjects: Adult; AIDS/HIV; Anthropometry; Biological and medical sciences; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cholesterol - blood; Cohort Studies; Counseling; Diet; Diet Records; dieta; Dietary Fats - administration & dosage; Dietary Services; Eating; Energy Intake; Female; femme; food intake; genero humano; genre humain; Health aspects; herpetoviridae; HIV; HIV infection; HIV Infections - diet therapy; HIV Infections - immunology; HIV Infections - metabolism; HIV Infections - mortality; HIV patients; hombres; homme; Human immunodeficiency virus; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; ingestion de alimentos; Life Tables; Male; mankind; Medical sciences; men; mujeres; Nutrition Assessment; Nutrition counseling; peso; poids; prise alimentaire homme; Prospective Studies; reduccion del peso; regime alimentaire; regime pour reduction de poids; Serum Albumin - analysis; Survival Analysis; Weight; Weight Loss; weight reduction; women; Infection; Human; Immunopathology; Dietary allowance; Food intake; Viral disease; Body weight; Weight loss; AIDS; Immune deficiency; Nutritional status
• ISSN: 0002-8223; 2212-2672; 1878-3570; 2212-2680
• DOI: 10.1016/S0002-8223(95)00115-8

Objective To define relationships among dietary intake and counseling, weight maintenance, and the clinical course of patients infected with the human immunodeficiency virus(HIV). Design A prospective cohort study in an HIV clinic in a county hospital. Subjects HIV-infected patients (68 with and 40 without acquired immunodeficiency syndrome [AIDS]) who had a good performance status and no chronic diarrhea were assessed at entry to the study and after 6 months. The following assessments were made: energy and nutrient intake based on 7-day food records, anthropometric measurements, immunologic function as lymphocyte T-cell subpopulations (ratio of CD4 to CD8), and serum cholesterol level. Patients were monitored to determine clinical outcome. Intervention All patients received standardized dietary counseling designed to address identified intake deficiencies and maintain body weight. Main outcome measures Changes in energy and nutrient intake, body weight, and clinical outcome (ie, time to AIDS-defining illness and overall survival time). Statistical analyses performed Group differences (HIV group vs AIDS group) were sought using χ 2 analyses and Student's t test. A multivariate regression model was used to determined the best predictors of clinical outcome. Results At baseline, total energy intake (based on 30 kcal/kg usual body weight) was adequate in both HIV and AIDS patients (101±4% and 103±5% [mean±standard deviation] of need, respectively). Despite dietary counseling and continued maintenance of energy intake, body weight, serum cholesterol level, and CD4 level progressively decreased. Consequently, saturated fat intake was found to be inversely related ( P<.01) to serum cholesterol level. Clinical outcome (after 3.5 years) was associated with baseline ratio of CD4 to CD8 ( P<.0001), weight ( P<.01), and serum cholesterol level ( P<.001). Multivariate analysis related ratio of CD4 to CD8 ( P<.001) and weight maintenance ( P<.001) to favorable outcome in the final model. Applications Weight loss in patients with HIV infection is independently prognostic of clinical outcome, and development of hypocholesterolemia is not favorable for clinical outcome. Because weight loss progresses despite conventional dietary counseling to identify energy need, interventions earlier in the disease course should be considered along with increased target levels for energy intake. J Am Diet Assoc. 1995; 95:428–432, 435.