Master Regulator Analysis of the SARS-CoV-2/Human Interactome

The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out...

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Published inJournal of clinical medicine Vol. 9; no. 4; p. 982
Main Authors Guzzi, Pietro H., Mercatelli, Daniele, Ceraolo, Carmine, Giorgi, Federico M.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2020
MDPI
Subjects
Clinical medicine
Coronaviruses
Datasets
Middle East respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viruses
China
Hubei China
COVID-19
gene network analysis
coronavirus
SARS-CoV-2
bioinformatics
Online AccessGet full text

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Abstract The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
AbstractList The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
Author Ceraolo, Carmine
Giorgi, Federico M.
Guzzi, Pietro H.
Mercatelli, Daniele
AuthorAffiliation 2 Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy; daniele.mercatelli2@unibo.it (D.M.); carmine.ceraolo@studio.unibo.it (C.C.)
1 Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro, Italy; hguzzi@unicz.it
AuthorAffiliation_xml – name: 1 Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro, Italy; hguzzi@unicz.it
– name: 2 Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy; daniele.mercatelli2@unibo.it (D.M.); carmine.ceraolo@studio.unibo.it (C.C.)
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  fullname: Guzzi, Pietro H.
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  orcidid: 0000-0003-3228-0580
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  fullname: Mercatelli, Daniele
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  surname: Ceraolo
  fullname: Ceraolo, Carmine
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  givenname: Federico M.
  orcidid: 0000-0002-7325-9908
  surname: Giorgi
  fullname: Giorgi, Federico M.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32244779$$D View this record in MEDLINE/PubMed
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SubjectTerms Clinical medicine
Coronaviruses
Datasets
Middle East respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viruses
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