Master Regulator Analysis of the SARS-CoV-2/Human Interactome

The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out...

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Bibliographic Details
Published inJournal of clinical medicine Vol. 9; no. 4; p. 982
Main Authors Guzzi, Pietro H., Mercatelli, Daniele, Ceraolo, Carmine, Giorgi, Federico M.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2020
MDPI
Subjects
Clinical medicine
Coronaviruses
Datasets
Middle East respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viruses
China
Hubei China
COVID-19
gene network analysis
coronavirus
SARS-CoV-2
bioinformatics
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Summary:The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9040982