Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives

• Published in: Marine drugs Vol. 17; no. 2; p. 80
• Main Authors: Chen, Jianwei, Wang, Bixia, Lu, Yaojia, Guo, Yuqi, Sun, Jiadong, Wei, Bin, Zhang, Huawei, Wang, Hong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.01.2019; MDPI
• Subjects: Actinomycetes; Adjuvants; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Bacteria; Bacterial infections; Bioassays; Biofilms; Biosynthesis; Competition; derivatives; E coli; Fungi; Gene expression; Gram-negative bacteria; Gram-positive bacteria; Inhibitors; Kinases; marine microorganism; Marine microorganisms; Metabolites; Microbiological strains; Microorganisms; Pathogenicity; Pathogens; Peptides; Proteins; Quorum sensing; quorum sensing inhibitor; Review; Virulence; marine microorganism; derivatives; quorum sensing; quorum sensing inhibitor
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md17020080

Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.