Metal-based imaging agents: progress towards interrogating neurodegenerative disease
Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of the malfunctions underpinning disease progression wi...
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| Published in | Chemical Society reviews Vol. 49; no. 1; pp. 2886 - 2915 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
21.05.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of the malfunctions underpinning disease progression will prove requisite in developing new treatments and cures. Transition metals and lanthanide ions display unique characteristics (
i.e.
, magnetism, radioactivity, and luminescence), often with biological relevance, allowing for direct application in CNS focused imaging modalities. These techniques include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and luminescent-based imaging (LumI). In this
Tutorial Review
, we have aimed to highlight the various metal-based imaging techniques developed in the effort to understand the pathophysiological processes associated with neurodegeneration. Each section has been divided so as to include an introduction to the particular imaging technique in question. This is then followed by a summary of key demonstrations that have enabled visualization of a specific neuropathological biomarker. These strategies have either exploited the high binding affinity of a receptor for its corresponding biomarker or a specific molecular transformation caused by a target species, all of which produce a concomitant change in diagnostic signal. Advantages and disadvantages of each method with perspectives on the utility of molecular imaging agents for understanding the complexities of neurodegenerative disease are discussed.
Transition metals and lanthanide ions display unique properties that enable the development of non-invasive diagnostic tools for imaging. In this review, we highlight various metal-based imaging strategies used to interrogate neurodegeneration. |
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| Bibliography: | Pete Harvey received his MChem (2009) and PhD (2013) with Prof David Parker FRS in the Chemistry Department at Durham University. He was then awarded an ESPRC Doctoral Prize Fellowship to work at The University of Manchester. In 2015, he was awarded a Wellcome Trust-MIT Postdoctoral Fellowship in the Department of Biological Engineering at MIT. He recently began his independent career in molecular MRI as a Nottingham Research Fellow. Graham Smith obtained his PhD from the University of Surrey and was a PDRA at Newcastle University and Imperial College. In 2011 he became a Lecturer in Molecular Imaging at the University of Hull where he helped establish a new PET research facility. In 2013 he moved to the Institute of Cancer Research to lead radiochemistry development within the Division of Radiotherapy and Imaging. Adam C. Sedgwick received his MChem (2014) and PhD (2018) with Tony D. James and Steven D. Bull at the University of Bath. He is now a postdoctoral research fellow working under the supervision of Prof. Jonathan L. Sessler at The University of Texas in Austin. His research interests are in the realms of stimuli-responsive materials, molecular imaging agents, and theranostic agents. He Tian was born in China in 1962. In 1999, he was appointed Cheung Kong Distinguished Professor by the Education Ministry of China. In 2011, he was selected as a member of the Chinese Academy of Science. He has been listed by Thomson Reuters as a Highly Cited Researcher in Chemistry (2014) and Materials Science (2014-2019). Tony D. James is a Professor at the University of Bath and Fellow of the Royal Society of Chemistry. He received his BSc from the University of East Anglia (1986), PhD from the University of Victoria (1991), was Postdoctoral Research with Seiji Shinkai (1991-1995) and Royal Society University Research Fellow at the University of Birmingham (1995-2000). He was awarded the Daiwa-Adrian Prize (2013), Inaugural CASE Prize (2015), MSMLG Czarnik Award (2018) and currently holds a prestigious Royal Society Wolfson Research Merit Award. (2017-2022). Diana A. Iovan received her BS in chemistry in 2012 from the University of Richmond. She then moved to Harvard University for her graduate studies with Prof. Ted Betley. After earning her PhD in inorganic chemistry in 2017, Diana joined Prof. Chris Chang's laboratory at UC Berkeley as a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation. James T. Brewster II grew up in Valley Center, California and obtained his BS with honours in chemistry from the University of California, Irvine with mentorship from Professor Kelvin W. Gee, Dr Derk J. Hogenkamp, and Dr Timothy Johnstone. James recently finished his PhD with Professor Jonathan L. Sessler at The University of Texas. James is currently conducting his postdoctoral work with Professor Andrew G. Myers at Harvard University. Xiao-Peng He is professor at Feringa Nobel Prize Scientists Research Center, School of Chemistry and Molecular Engineering, ECUST. He obtained his BSc (2006) and PhD (2011) from ECUST. He completed a co-tutored doctoral program at ENS Cachan (France) (2008 to 2009) and postdoctoral research with Kaixian Chen (SIMM, CAS) from 2011 to 2013 at ECUST. Jonathan L. Sessler received a BSc degree in Chemistry in 1977 from the University of California, Berkeley. He obtained his PhD from Stanford University in 1982. After postdoctoral stays in Strasbourg and Kyoto, he accepted a position as an Assistant Professor of Chemistry at the University of Texas at Austin, where he is currently the Doherty-Welch Chair. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c8cs00986d |