Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study
OBJECTIVES The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception. BACKGROUND Few ischemic episodes are associated with angina; symptoms have been related to pain perception thresholds. METHODS A total of 196 patients with documented co...
Saved in:
Published in | Journal of the American College of Cardiology Vol. 33; no. 7; pp. 1855 - 1862 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.06.1999
Elsevier Science |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | OBJECTIVES
The purpose of this study was to test whether cutaneous thermal pain thresholds are related to anginal pain perception.
BACKGROUND
Few ischemic episodes are associated with angina; symptoms have been related to pain perception thresholds.
METHODS
A total of 196 patients with documented coronary artery disease underwent bicycle exercise testing and thermal pain testing. The Marstock test of cutaneous sensory perception was administered at baseline after 30 min of rest on two days and after exercise and mental stress. Resting hot pain thresholds (HPTs) were averaged for the two baseline visits and divided into two groups: 1) average HPT <41°C, and 2) average HPT ≥41°C, to be clearly indicative of abnormal hypersensitivity to noxious heat.
RESULTS
Patients with HPT <41°C had significantly shorter time to angina onset on exercise testing than patients with HPT ≥41°C (p < 0.04, log-rank test). Heart rates, systolic blood pressure and rate–pressure product at peak exercise were not different for the two groups. Resting plasma beta-endorphin levels were significantly higher in the HPT <41°C group (5.9 ± 3.7 pmol/liter vs. 4.7 ± 2.8 pmol/liter, p = 0.02). Using a Cox proportional hazards model, patients with HPT <41°C had an increased risk of angina (p = 0.03, rate ratio = 2.0). These differences persisted after adjustment for age, gender, depression, anxiety and history of diabetes or hypertension (p < 0.01).
CONCLUSIONS
Occurrence of angina and timing of angina onset on an exercise test are related to overall hot pain sensory perception. The mechanism of this relationship requires further study. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0735-1097 1558-3597 |
DOI: | 10.1016/S0735-1097(99)00099-6 |