Chemically Diverse and Biologically Active Secondary Metabolites from Marine Phylum chlorophyta

• Published in: Marine drugs Vol. 18; no. 10; p. 493
• Main Authors: Shah, Sayed Asmat Ali, Hassan, Syed Shams Ul, Bungau, Simona, Si, Yongsheng, Xu, Haiwei, Rahman, Md Habibur, Behl, Tapan, Gitea, Daniela, Pavel, Flavia-Maria, Corb Aron, Raluca Anca, Pasca, Bianca, Nemeth, Sebastian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.09.2020; MDPI
• Subjects: Algae; alkaloids; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-inflammatory agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Betacoronavirus - drug effects; Bioactive compounds; Biological activity; Biological Products - chemistry; Biological Products - pharmacology; Biological properties; Cancer; Chemical compounds; Chlorophyta - chemistry; Chlorophyta - metabolism; chlorophytes; Coronavirus Infections - drug therapy; Coronavirus Infections - virology; COVID-19; Drugs; fatty acid; Fatty acids; Freshwater; Functional foods & nutraceuticals; Functional groups; Glycerides; HIV; Human immunodeficiency virus; Humans; Industry; Inflammation; Inland water environment; Metabolites; Mode of action; Natural products; Neoplasms - drug therapy; Pandemics; Pathogens; Pharmaceutical industry; Pneumonia, Viral - drug therapy; Pneumonia, Viral - virology; Review; SARS-CoV-2; Secondary metabolites; Severe acute respiratory syndrome coronavirus 2; Steroid hormones; steroids; Terpenes; Terrestrial environments; East China Sea; lipids; glycerides; terpenes; alkaloids; chlorophytes; fatty acid; steroids
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md18100493

For a long time, algal chemistry from terrestrial to marine or freshwater bodies, especially chlorophytes, has fascinated numerous investigators to develop new drugs in the nutraceutical and pharmaceutical industries. As such, chlorophytes comprise a diverse structural class of secondary metabolites, having functional groups that are specific to a particular source. All bioactive compounds of chlorophyte are of great interest due to their supplemental/nutritional/pharmacological activities. In this review, a detailed description of the chemical diversity of compounds encompassing alkaloids, terpenes, steroids, fatty acids and glycerides, their subclasses and their structures are discussed. These promising natural products have efficiency in developing new drugs necessary in the treatment of various deadly pathologies (cancer, HIV, SARS-CoV-2, several inflammations, etc.). Marine chlorophyte, therefore, is portrayed as a pivotal treasure in the case of drugs having marine provenience. It is a domain of research expected to probe novel pharmaceutically or nutraceutically important secondary metabolites resulting from marine . In this regard, our review aims to compile the isolated secondary metabolites having diverse chemical structures from chlorophytes (like ssp., ssp., ssp., ssp., ssp., ssp., ssp.), their biological properties, applications and possible mode of action.