A Year at the Forefront of Proteostasis and Aging

• Published in: Biology open Vol. 12; no. 2
• Main Authors: Thompson, Maximilian A, De-Souza, Evandro A
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.02.2023; The Company of Biologists
• Series: A Year at the Forefront
• Subjects: Aging; Aging - metabolism; Animals; cell non-autonomous response; Cellular stress response; Chronic illnesses; heat shock response; longevity; Protein folding; protein homeostasis; Proteins - metabolism; Proteostasis - physiology; Review; upr; Heat shock response; Cell non-autonomous response; Longevity; Protein homeostasis; UPR
• ISSN: 2046-6390; 2046-6390
• DOI: 10.1242/bio.059750

During aging, animals experience a decline in proteostasis activity, including loss of stress-response activation, culminating in the accumulation of misfolded proteins and toxic aggregates, which are causal in the onset of some chronic diseases. Finding genetic and pharmaceutical treatments that can increase organismal proteostasis and lengthen life is an ongoing goal of current research. The regulation of stress responses by cell non-autonomous mechanisms appears to be a potent way to impact organismal healthspan. In this Review, we cover recent findings in the intersection of proteostasis and aging, with a special focus on articles and preprints published between November 2021 and October 2022. A significant number of papers published during this time increased our understanding of how cells communicate with each other during proteotoxic stress. Finally, we also draw attention to emerging datasets that can be explored to generate new hypotheses that explain age-related proteostasis collapse.