Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer

• Published in: Marine drugs Vol. 15; no. 9; p. 283
• Main Authors: Morin, Caroline, Rodríguez, Enrique, Blier, Pierre U, Fortin, Samuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.09.2017; MDPI
• Subjects: Activation; Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; AKT protein; Animals; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Aquatic Organisms; Cancer; Cell proliferation; Cell Proliferation - drug effects; Cells; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - parasitology; Data processing; EGFR; Eicosapentaenoic acid; Eicosapentaenoic Acid - pharmacology; Eicosapentaenoic Acid - therapeutic use; EPA; Epidermal growth factor receptors; Female; HCT116 Cells - drug effects; Health risks; HIF1α; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Mode of action; Monoglycerides - pharmacology; Monoglycerides - therapeutic use; Neoplasms; Oils & fats; Proliferation; Tumors; Vascular endothelial growth factor; Vascular endothelial growth factor receptors; VEGF; Xenografts; apoptosis; colorectal carcinoma; HIF1α; VEGF; EGFR; EPA
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md15090283

There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells. The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft. Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors. MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells.