ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer

• Published in: Journal of clinical oncology Vol. 24; no. 33; pp. 5313 - 5327
• Main Authors: LOCKER, Gershon Y, HAMILTON, Stanley, HARRIS, Jules, JESSUP, John M, KEMENY, Nancy, MACDONALD, John S, SOMERFIELD, Mark R, HAYES, Daniel F, BAST, Robert C
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 20.11.2006; Lippincott Williams & Wilkins
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - blood; CA-19-9 Antigen - blood; Carcinoembryonic Antigen - blood; Colorectal Neoplasms - blood; Colorectal Neoplasms - chemistry; DCC Receptor; Dihydrouracil Dehydrogenase (NADP) - analysis; DNA, Neoplasm; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Neoplasms - blood; Gastrointestinal Neoplasms - chemistry; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - therapy; Genes, ras; Humans; Immunohistochemistry; Loss of Heterozygosity; Mass Screening - methods; Medical sciences; Microsatellite Instability; Mutation; Ploidies; Polymerase Chain Reaction; Population Surveillance; Predictive Value of Tests; Primary Prevention - methods; Receptors, Cell Surface - analysis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Thymidine Phosphorylase - analysis; Thymidylate Synthase - analysis; Tumor Suppressor Protein p53 - blood; Tumor Suppressor Proteins - analysis; Tumors; Cancerology; Gastrointestinal cancer; Digestive diseases; Intestinal disease; Tumoral marker; Malignant tumor; Recommendation; Cancer; Gastric disease
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2006.08.2644

To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of gastrointestinal cancers. For the 2006 update, an update committee composed of members from the full Panel was formed to complete the review and analysis of data published since 1999. Computerized literature searches of Medline and the Cochrane Collaboration Library were performed. The Update Committee's literature review focused attention on available systematic reviews and meta-analyses of published tumor marker studies. For colorectal cancer, it is recommended that carcinoembryonic antigen (CEA) be ordered preoperatively, if it would assist in staging and surgical planning. Postoperative CEA levels should be performed every 3 months for stage II and III disease for at least 3 years if the patient is a potential candidate for surgery or chemotherapy of metastatic disease. CEA is the marker of choice for monitoring the response of metastatic disease to systemic therapy. Data are insufficient to recommend the routine use of p53, ras, thymidine synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, microsatellite instability, 18q loss of heterozygosity, or deleted in colon cancer (DCC) protein in the management of patients with colorectal cancer. For pancreatic cancer, CA 19-9 can be measured every 1 to 3 months for patients with locally advanced or metastatic disease receiving active therapy. Elevations in serial CA 19-9 determinations suggest progressive disease but confirmation with other studies should be sought. New markers and new evidence to support the use of the currently reviewed markers will be evaluated in future updates of these guidelines.