Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children

• Published in: Nutrients Vol. 10; no. 6; p. 680
• Main Authors: Brett, Neil R, Lavery, Paula, Agellon, Sherry, Vanstone, Catherine A, Goruk, Susan, Field, Catherine J, Weiler, Hope A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2018; MDPI
• Subjects: 25-Hydroxyvitamin D; 25-Hydroxyvitamin D 2 - blood; Biomarkers - blood; Calcifediol - blood; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Children; Cross-Sectional Studies; Cytokines; Female; Follow-Up Studies; Food, Fortified; Fortified foods; Humans; Illnesses; immune function; Immune response; Immune System - immunology; Immune System - physiopathology; Infant; Inflammation Mediators - blood; Influenza, Human - immunology; Influenza, Human - prevention & control; Interleukin 6; Leukocytes; Leukocytes (mononuclear); Lymphocytes; Male; Nutrition Assessment; Nutritional Status; Peripheral blood; Quebec; Respiratory Tract Infections - immunology; Respiratory Tract Infections - prevention & control; Seasons; Tumor necrosis factor-α; Urban Health; Vitamin D; Vitamin D - administration & dosage; Vitamin D - therapeutic use; Vitamin D Deficiency - blood; Vitamin D Deficiency - immunology; Vitamin D Deficiency - physiopathology; Vitamin D Deficiency - prevention & control; children; immune function; vitamin D
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu10060680

In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years ( = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old ( = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher ( < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.