Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study

• Published in: Materials Vol. 14; no. 5; p. 1126
• Main Authors: Huchim-Chablé, María, de Arredondo, Roberto Sosa-Martínez, Rivero-Navarrete, José Alberto, Mendiburu-Zavala, Celia, Cárdenas-Erosa, Rubén, Peñaloza-Cuevas, Ricardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.02.2021; MDPI
• Subjects: Alveoli; Angiogenesis; bone regeneration; Calcium sulfate; Cell adhesion & migration; Dentistry; Evaluation; Fibroblasts; graft; Growth factors; Hydroxyapatite; Patients; Plasma; PRGF; Quadrants; Radiopacity; Regeneration (physiology); Substitute bone; X-rays; Mexico; Chicago Illinois; United States > US; Spain; bone regeneration; calcium sulfate; PRGF; graft
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma14051126

The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO + PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO + PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups = 0.002 ( < 0.05). Significant differences were observed in all quadrants and areas = 0.002 ( < 0.05) except in area A in month 4 ( = 0.016), which could be explained by its being the closest to native bone. EG CaSO + PRGF showed a higher degree of bone regeneration compared to CG.