Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review

To find out whether food-producing animals (FPAs) are a source of extraintestinal expanded-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) infections in humans, Medline, Embase, and the Cochrane Database of Systematic Reviews were systematically reviewed. Thirty-four original, peer-revie...

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Bibliographic Details
Published inClinical infectious diseases Vol. 60; no. 3; pp. 439 - 452
Main Authors Lazarus, Benjamin, Paterson, David L., Mollinger, Joanne L., Rogers, Benjamin A.
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.02.2015
Subjects
Animals
Cephalosporin Resistance
Disease transmission
Drug resistance
Drug Resistance, Multiple, Bacterial
E coli
Epidemiology
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Escherichia coli Infections - transmission
FOOD SAFETY
Genetics
Humans
Livestock - microbiology
Poultry
Poultry - microbiology
Systematic review
Zoonoses - transmission
Netherlands
ESBL
urinary tract
poultry
zoonosis
ST131
E. coli
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Summary:To find out whether food-producing animals (FPAs) are a source of extraintestinal expanded-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) infections in humans, Medline, Embase, and the Cochrane Database of Systematic Reviews were systematically reviewed. Thirty-four original, peer-reviewed publications were identified for inclusion. Six molecular epidemiology studies supported the transfer of resistance via whole bacterium transmission (WBT), which was best characterized among poultry in the Netherlands. Thirteen molecular epidemiology studies supported transmission of resistance via mobile genetic elements, which demonstrated greater diversity of geography and host FPA. Seventeen molecular epidemiology studies did not support WBT and two did not support mobile genetic element–mediated transmission. Four observational epidemiology studies were consistent with zoonotic transmission. Overall, there is evidence that a proportion of human extraintestinal ESCR-EC infections originate from FPAs. Poultry, in particular, is probably a source, but the quantitative and geographical extent of the problem is unclear and requires further investigation.
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ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciu785