PET kinetic analysis--compartmental model

PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data. This review describes the principle of the compartmental model and categorizes the techniques and app...

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Bibliographic Details
Published inAnnals of nuclear medicine Vol. 20; no. 9; pp. 583 - 588
Main Authors Watabe, Hiroshi, Ikoma, Yoko, Kimura, Yuichi, Naganawa, Mika, Shidahara, Miho
Format Journal Article
LanguageEnglish
Published Japan Springer Nature B.V 01.11.2006
Subjects
Computer Simulation
Data Interpretation, Statistical
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Kinetics
Magnetic Resonance Imaging
Models, Theoretical
Neoplasm Staging
Positron-Emission Tomography - instrumentation
Positron-Emission Tomography - methods
Radioisotopes - pharmacokinetics
Telencephalon - pathology
Tomography, Emission-Computed, Single-Photon - methods
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Summary:PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data. This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmental model according to various aspects: model design, experimental design, invasiveness, and mathematical solution. We also discussed advanced applications of the compartmental analysis with PET.
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ISSN:0914-7187
1864-6433
DOI:10.1007/BF02984655