Synthesis of Silver Nanoparticles Using Odontosoria chinensis (L.) J. Sm. and Evaluation of their Biological Potentials

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 13; no. 4; p. 66
• Main Authors: Antonysamy Johnson, Marimuthu Alias, Shibila, Thangaiah, Amutha, Santhanam, Menezes, Irwin R A, da Costa, José G M, Sampaio, Nadghia F L, Coutinho, Henrique D M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.04.2020; MDPI
• Subjects: Acids; anti-diabetic; anti-inflammatory; cytotoxic; Diabetes; Drinking water; Experiments; Nanoparticles; Odontosoria chinenesis; silver nanoparticles; Spectrum analysis; Toxicity; India; anti-inflammatory; Odontosoria chinenesis; anti-diabetic; silver nanoparticles; cytotoxic
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph13040066

The present study was aimed to synthesize silver nanoparticles (AgNPs) from the aqueous extracts of (L.) J. Sm. and the synthesized AgNPs were examined for their biopotentials. The extracts were added to 1 mM AgNO solution with different ratios viz., 0.5: 9.5, 1:9, 1.5: 8.5 and 2: 8 ratios for the reduction of Ag ions. After reduction, the AgNPs of were analyzed spectroscopically for further confirmation. The synthesized AgNPs of were characterized by pH, ultra violet-visible spectroscopy (UV-Vis), Fourier transform-infra red spectroscopy (FT-IR), scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDAX) and X-Ray diffraction (XRD). The time taken for the complete reduction of Silver (Ag) in solution to nanoparticle was 10 min. The aqueous extracts mediated silver nanoparticles showed a broad peak with distinct absorption at around 400-420 nm and confirmed the silver nanoparticle formation. FT-IR results also confirmed the existence of organic materials in the silver nanoparticles of . The EDX spectra of AgNPs of revealed the occurrence of a strong Ag peak. The synthesis of AgNPs of was confirmed with the existence of a peak at 46.228°. The toxic potential of AgNPs of showed varied percentage mortality with the LC values of 134.68 μL/ 50 mL and 76.5 μL/50 mL, respectively. The anti-inflammatory and anti-diabetic activities of aqueous and AgNPs of were statistically significant at < 0.05 level. Conclusion: The results demonstrated the toxicity, anti-diabetic and anti-inflammatory potential of the studied AgNPs The synthesized nanoparticles of could be tested as an alternative to anticancer, anti-diabetic and anti-inflammatory drugs.