Chemical constituents on the aerial parts of Artemisia selengensis and their IL-6 inhibitory activity

• Published in: Archives of pharmacal research Vol. 38; no. 6; pp. 1059 - 1065
• Main Authors: Kim, A Ryun, Ko, Hae Ju, Chowdhury, Md Anisuzzaman, Chang, Young-Su, Woo, Eun-Rhan
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.06.2015; 대한약학회
• Subjects: aerial parts; Artemisia; Artemisia - chemistry; caffeoylquinic acid; Cell Line; chemical composition; Chromatography, High Pressure Liquid; eupatilin; interleukin-6; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - biosynthesis; isoquercitrin; Magnetic Resonance Spectroscopy; Medicine; nuclear magnetic resonance spectroscopy; Pharmacology/Toxicology; Pharmacy; Plant Components, Aerial - chemistry; Research Article; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - pharmacology; 약학; IL-6 inhibitory activity; 1′,3′-propanediol,2′-amino-1′-(1,3-benzodioxol-5-yl); Compositae; Turcz
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-014-0543-x

Ten compounds, 1′,3′-propanediol,2′-amino-1′-(1,3-benzodioxol-5-yl) (1), artanomaloide (2), canin (3), eupatilin (4), quercetin-3-O-β-D-glucoside-7-O-α-L-rhamnoside (5), 1,3-di-O-caffeoylquinic acid (6), isoquercitrin (7), pinoresinol-4-O-β-D-glucoside (8), scopolin (9), and isofraxidin-7-O-β-D-glucopyranoside (10) were isolated from the aerial parts of A. selengensis. The structures of compounds (1–10) were identified based on 1D and 2D NMR, including ¹H–¹H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among them, compound 1 was isolated from this plant for the first time as a naturally occurring compound. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cells was also examined.