Effects of omega-3 fatty acid supplementation on vascular access thrombosis in polytetrafluorethylene grafts

• Published in: Journal of renal nutrition Vol. 17; no. 2; p. 126
• Main Authors: Bowden, Rodney G, Wilson, Ronald L, Gentile, Mindy, Ounpraseuth, Songthip, Moore, Page, Leutholtz, Brian C
• Format: Journal Article
• Language: English
• Published: United States 01.03.2007
• Subjects: Arteriovenous Shunt, Surgical - adverse effects; Biocompatible Materials; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Omega-3 - therapeutic use; Humans; Polytetrafluoroethylene; Prospective Studies; Thrombosis - etiology; Thrombosis - prevention & control; Vascular Patency - drug effects
• ISSN: 1532-8503
• DOI: 10.1053/j.jrn.2006.07.009

The purpose of this study was to investigate the effects of orally administered over-the-counter omega-3 (n-3) fatty acid supplements on primary patency of polytetrafluoroethylene (PTFE) grafts. This study was conducted with a triple-blind, permuted-block, randomized, placebo-controlled experimental design. Dialysis clinics with patients who, in accordance with physician diagnosis, needed a new PTFE graft. Patients on long-term hemodialysis with newly placed PTFE grafts who were unable to receive a native arteriovenous fistula. Patients were followed prospectively for 8 months after they had been placed into an n-3 fatty acid or control group and were monitored for primary patency. Primary patency of the PTFE graft. The n-3 fatty acid group had a mean PTFE graft primary patency rate of 254.2 days (SEM = 51.8), and the control group had a mean PTFE graft primary patency rate of 254.1 days (SEM = 34.6), revealing no significant difference in survival time between groups. No significant differences in primary patency rates were noted in the experimental and control groups.