The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world. Today, cone snails have attracted attention for their remarkable venom components. Many conotoxins are proving valuable as res...

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Bibliographic Details
Published inMarine drugs Vol. 15; no. 5; p. 145
Main Authors Robinson, Samuel D., Li, Qing, Lu, Aiping, Bandyopadhyay, Pradip K., Yandell, Mark, Olivera, Baldomero M., Safavi-Hemami, Helena
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.05.2017
MDPI
Subjects
Amino Acid Sequence
Animals
Components
cone snail
conotoxin
Conotoxins
Conotoxins - chemistry
Conotoxins - pharmacology
Conus
Conus gloriamaris
Conus Snail - physiology
Drugs
Gene expression
History
Identification
Marine molluscs
Mollusk Venoms - chemistry
Mollusk Venoms - metabolism
Pharmaceutical industry
Snails
Toxins
Transcriptome
Venom
Venom gland
cone snail
conotoxin
venom
Conus
Conus gloriamaris
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ISSN1660-3397
1660-3397
DOI10.3390/md15050145

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Summary:The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world. Today, cone snails have attracted attention for their remarkable venom components. Many conotoxins are proving valuable as research tools, drug leads, and drugs. In this article, we present the venom gland transcriptome of C. gloriamaris, revealing this species’ conotoxin repertoire. More than 100 conotoxin sequences were identified, representing a valuable resource for future drug discovery efforts.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md15050145